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Charcoal and Isoniazid Pharmacokinetics

Department of Clinical Pharmacology, University of Wales College of Medicine, Llandough Hospital, South Glamorgan CF6 1XX, Wales, UK

M.J. Ward

Department of Clinical Pharmacology, University of Wales College of Medicine, Llandough Hospital, South Glamorgan CF6 1XX, Wales, UK

A. Hutchings

Department of Clinical Pharmacology, University of Wales College of Medicine, Llandough Hospital, South Glamorgan CF6 1XX, Wales, UK

P.A. Routledge

Department of Clinical Pharmacology, University of Wales College of Medicine, Llandough Hospital, South Glamorgan CF6 1XX, Wales, UK

Activated charcoal (10 g) administered 1 h after a 600 mg oral dose of isoniazid to six healthy subjects did not reduce the area under the plasma concentration-time curve for isoniazid significantly. Charcoal administration is unlikely to be of value in isoniazid poisoning if delayed by an hour or more after the overdose.

Human & Experimental Toxicology, Vol. 5, No. 4, 285-286 (1986)
DOI: 10.1177/096032718600500414


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