SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ferner, R.E.
Right arrow Articles by Rawlins, M.D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ferner, R.E.
Right arrow Articles by Rawlins, M.D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Massive Glibenclamide Overdose without Hypoglycaemia in a Man with Diabetes after Partial Pancreatectomy

R.E. Ferner

Wolfson Unit of Clinical Pharmacology

K.G.M.M. Alberti

Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne NE14LP, UK

M.D. Rawlins

Wolfson Unit of Clinical Pharmacology

A 49-year-old man with non-insulin-dependent diabetes mellitus (NIDDM) from alcoholic pancreatitis took 100 mg of glibenclamide without symptoms of hypoglycaemia even when glibenclamide concentrations were high (191 µg/l). There was no increase in serum C-peptide concentration. The observed half-life of glibenclamide was 6 h. It is concluded that (1) high doses of glibenclamide will not provoke pancreatic insulin secretion in NIDDM caused by pancreatic destruction, (2) there was no evidence for an acute extra-pancreatic effect of glibenclamide and (3) the elimination of glibenclamide may be slower than supposed previously.

Human & Experimental Toxicology, Vol. 5, No. 4, 283-284 (1986)
DOI: 10.1177/096032718600500413
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement