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Influence of Dosing Interval and In-patient Versus Out-patient Status on Incidence of Side-effects of Niridazole

Departments of Pharmacology and Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria

L. Sambo-Donga

Departments of Pharmacology and Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria

The side-effects of niridazole used for urinary schistosomiasis were studied prospectively over a 3-month period in male patients receiving the standard dose of 25 mg day^-1 kg^-1 for 7 days. Side-effects were detected in 80% of in-patients but only in 33% of out-patients. The range of side-effects was greater in in-patients taking their daily doses in two portions than in those taking theirs in three. Cure rates and degree of schistosoma egg suppression were significantly lower in out-patients suggesting that compliance with treatment was poorer.

Human & Experimental Toxicology, Vol. 5, No. 4, 275-278 (1986)
DOI: 10.1177/096032718600500410


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