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Human & Experimental Toxicology
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Theophylline Pharmacokinetics in Patients from a Geriatric Hospital: Influence of Cigarette Smoking

P.W. Trembath

Respiratory and Clinical Pharmacology Units, Austin Hospital, Heidelberg, Victoria

D.D. Thorsborne-Palmer

Respiratory and Clinical Pharmacology Units, Austin Hospital, Heidelberg, Victoria

B. Jarrott

Respiratory and Clinical Pharmacology Units, Austin Hospital, Heidelberg, Victoria

J.J. Hammond

National Research Institute of Gerontology and Geriatric Medicine, University of Melbourne, Mount Royal Hospital, Parkville, Victoria, Australia

D.M. Prinsley

National Research Institute of Gerontology and Geriatric Medicine, University of Melbourne, Mount Royal Hospital, Parkville, Victoria, Australia

The influence of cigarette smoking on plasma theophylline elimination half-life was examined in a group of elderly in-patients, to determine whether the modifying effect of cigarette smoking is also present in this age-group. The plasma theophylline half-life was determined in five non-smokers and seven smokers aged 66-88 years after administration of 320 mg of theophylline syrup. A wide range of plasma theophylline half-lives was observed in each group. However, there was a significant difference (P < 0.05) between the mean plasma theophylline half-life in smokers (5.41 h, SEM 0.69 h) and non-smokers (10.40 h, SEM 1.90 h). It was concluded that, although plasma theophylline half-life tends to be longer in this age-group, the modifying influence of cigarette smoking on plasma theophylline half-life can be demonstrated in the elderly, as well as in young adults.

Human & Experimental Toxicology, Vol. 5, No. 4, 265-268 (1986)
DOI: 10.1177/096032718600500408
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