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Human & Experimental Toxicology
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Potato Steroidal Alkaloids and Neural Tube Defects: Serum Concentrations Fail to Demonstrate a Causal Relation

M.H. Harvey

Department of Chemical Pathology, Lewisham Group Laboratory, Lewisham Hospital, London SE13 6LH

B.A. Morris

Division of Clinical Biochemistry, Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH, UK

M. McMillan

Department of Chemical Pathology, Lewisham Group Laboratory, Lewisham Hospital, London SE13 6LH

V. Marks

Division of Clinical Biochemistry, Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH, UK

Spoiled potatoes and, in particular, steroidal alkaloids have been proposed as an aetiological factor in the pathogenesis of neural tube defect (NTD). The present study involves the measurement of potato (solanum) steroidal alkaloid concentrations in serum by radioimmunoassay. Serum solanidine and total potato alkaloid concentrations were measured in two groups of women: one group pregnant with a fetus, subsequently shown to be affected by a NTD, the other with a healthy fetus. Serum alkaloid concentrations were, contrary to expectations, lower in the NTD group. They lend no weight therefore to the theory that potato alkaloids are responsible for NTD, but are consistent with the opinion that some water-soluble vitamins lessen the risk.

Human & Experimental Toxicology, Vol. 5, No. 4, 249-253 (1986)
DOI: 10.1177/096032718600500406
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