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Arterial-Venous Plasma Concentration Differences of Meprobamate in Acute Human Poisonings

Clinique Toxicologique (Pr. P. E. Fournier), Hôpital Fernand Widal- 200, rue du Faubourg Saint Denis, 75475 Paris Cedex 10, Universite Paris V, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Niihari-Gun, Ibaraki-Ken, 305 Japan

F.J. Baud

Clinique Toxicologique (Pr. P. E. Fournier), Hôpital Fernand Widal- 200, rue du Faubourg Saint Denis, 75475 Paris Cedex 10, Universite Paris V

C. Bismuth

Clinique Toxicologique (Pr. P. E. Fournier), Hôpital Fernand Widal- 200, rue du Faubourg Saint Denis, 75475 Paris Cedex 10, Universite Paris V

M. Galliot

Laboratoire de Toxicologie (Pr. R. Bourdon), Hôpital Fernand Widal- 200, rue du Fauboug Saint Denis, 75010 Paris, France

E. Vicaut

Clinique Toxicologique (Pr. P. E. Fournier), Hôpital Fernand Widal- 200, rue du Faubourg Saint Denis, 75475 Paris Cedex 10, Universite Paris V

A. Buisine

Laboratoire de Toxicologie (Pr. R. Bourdon), Hôpital Fernand Widal- 200, rue du Fauboug Saint Denis, 75010 Paris, France

1 Arterial-venous plasma concentration differences of meprobamate were studied on admission of acute overdose in man.

2 The patients were divided in two groups. In the control group (n= 25) two successive blood samples were collected from the same vessel. In the study group ( n = 35) femoral arterial and venous blood samples were collected simultaneously.

3 In the control group the differences were not significant. In the study group the differences were statistically significant (P < 0.01).

4 The present study suggests that the origin of blood samples should be stated for toxicological studies and that the toxicokinetics may be more complex than those recognized previously.

Human & Experimental Toxicology, Vol. 5, No. 4, 243-248 (1986)
DOI: 10.1177/096032718600500405


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