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Human & Experimental Toxicology
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Assessment of Polymorphonucleate Leucocyte Functions in Adult Epileptic Patients Undergoing Long-term Phenytoin Treatment

G. Ricevuti

Department of Internal Medicine and Therapeutics, Sections of Medical Pathology and Pharmacology, University of Pavia, Piazza Botta 10, 1-27100 Pavia, Italy

M. Marcoli

Department of Internal Medicine and Therapeutics, Sections of Medical Pathology and Pharmacology, University of Pavia, Piazza Botta 10, 1-27100 Pavia, Italy

G. Gatti

Department of Internal Medicine and Therapeutics, Sections of Medical Pathology and Pharmacology, University of Pavia, Piazza Botta 10, 1-27100 Pavia, Italy

A. Mazzone

Department of Internal Medicine and Therapeutics, Sections of Medical Pathology and Pharmacology, University of Pavia, Piazza Botta 10, 1-27100 Pavia, Italy

S. Lecchini

Department of Internal Medicine and Therapeutics, Sections of Medical Pathology and Pharmacology, University of Pavia, Piazza Botta 10, 1-27100 Pavia, Italy

G.M. Frigo

Department of Internal Medicine and Therapeutics, Sections of Medical Pathology and Pharmacology, University of Pavia, Piazza Botta 10, 1-27100 Pavia, Italy

Twelve patients given more than 1 year phenytoin monotherapy and 12 healthy control subjects taking no drugs and matched for sex and age were examined for polymorphonucleate (PMN) functions. To assess PMN activity, cell locomotion and directed migration, phagocytosing ability and bactericidal activity were investigated. No change either in the absolute or relative counts of PMN leucocytes was found in the patients. However, a significant impairment of both PMN chemotaxis and stimulated Nitro Blue Tetrazolium reduction or superoxide anion generation was observed in the patients as compared with the control group of subjects.

Human & Experimental Toxicology, Vol. 5, No. 4, 237-241 (1986)
DOI: 10.1177/096032718600500404
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