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Desferrioxamine Administered Intravenously by Infusion Causes a Reduction in the Electroretinogram in Rabbits Anaesthetized with Urethane

Department of Clinical Ophthalmology, Institute of Ophthalmology, Judd Street, London WC1, UK

In rabbits anaesthetized with urethane, intravenous infusion of the iron-chelating drug desferrioxamine causes a reduction in the amplitude of the electroretinogram. This is most pronounced for weak light intensities, but the change is more complex than a mere reduction in sensitivity. In experiments lasting up to 3 days the effect is reversible and is not accompanied by electron-microscopical histological changes.

Human & Experimental Toxicology, Vol. 5, No. 4, 229-236 (1986)
DOI: 10.1177/096032718600500403


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