This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Swain, R. Articles by Bapna, J.S. Search for Related Content PubMed Articles by Swain, R. Articles by Bapna, J.S. Social Bookmarking                         What's this?

Impairment of Exercise Tolerance due to Broxyquinoline-Brobenzoxaldine Combination

Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry - 605006, India

J.S. Bapna

Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry - 605006, India

1 A case report of impaired exercise tolerance during administration of broxyquinoline-brobenzoxaldine combination in therapeutic doses is presented.

2 The first author of this paper, a 28-year-old healthy male, volunteered as a subject for a prospective study on the neurotoxicity of halogenated hydroxyquinolines and took a course of broxyquinoline-brobenzoxaldine combination.

3 The author, who is a karate enthusiast, observed impairment of exercise tolerance during the course of treatment with the drugs.

4 A challenge course of treatment with the same drugs in the same doses produced similar effects.

5 Since halogenated hydroxyquinolines are still used widely in many countries, such an adverse effect would be of practical relevance, particularly in asymptomatic cyst-passers of Entamoeba histolytica whose occupations involve physical labour.

Human & Experimental Toxicology, Vol. 5, No. 1, 63-64 (1986)
DOI: 10.1177/096032718600500115


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?