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Ergotamine-induced Peripheral Ischaemia Reversed by Oral Thymoxamine Hydrochloride

Department of Surgery, St Thomas' Hospital, London Bridge, London SE1 9TR, UK

L.D. Lewis

Department of Clinical Pharmacology, United Medical and Dental Schools of Guy's and St Thomas' Hospital, London Bridge, London SE1 9RT, UK

Although there is no generally accepted therapy for ergotamine-induced vasoconstriction, infusion of directly acting vasodilators is regarded presently as the treatment of choice. We present a case of peripheral arterial ischaemia secondary to excessive use of ergotamine suppositories, which was reversed with oral thymoxamine hydrochloride (an ₁-adrenoceptor antagonist) and ergotamine withdrawal. We suggest that in patients with ergotamine-induced peripheral arterial vasoconstriction with no evidence of gangrene, oral thymoxamine may be considered as a useful adjunct or possible alternative to infused vasodilator treatment.

Human & Experimental Toxicology, Vol. 5, No. 1, 61-62 (1986)
DOI: 10.1177/096032718600500114


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