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Haemoperfusion: a Useful Therapy for a Severely Poisoned Patient?

Department of Nephrology-Hypertension, University of Antwerp, Belgium

C. Bismuth

Hôpital Fernand Widal, Paris, France

G. De Groot

Rijksinstituut voor Volksgezondheid en Milieuhygiëne, Bilthoven, The Netherlands

A. Heath

Poisons Therapy Group, Sahlgrem Hospital, Gothenberg, Sweden

S. Okonek

Klinikum der Johannes-Gutenberg-Universität, Mainz, Germany

D.R. Ritz

Kantonspital, Basel, Switzerland

G.A. Verpooten

Department of Nephrology-Hypertension, University of Antwerp, Belgium

G.N. Volans

Poisons Unit, New Cross Hospital, London, UK

B. Widdop

Poisons Unit, New Cross Hospital, London, UK

Although it is many years since a haemodialysis and haemoperfusion over uncoated and later coated charcoal columns have been used for the treatment of intoxicated patients, the clinical efficacy of these extracorporeal techniques in the treatment of severely poisoned patients remains a matter of debate. Some of the reasons for this controversy may be the indiscriminate use of haemoperfusion in any form of intoxication, the lack of well-controlled studies and the wrong interpretation of the high haemoperfusion clearance values sometimes obtained. Simple pharmacokinetic principles are applied to this type of treatment and some practical guidelines as to how and when haemoperfusion should be applied or presented are reviewed. The limited place of haemoperfusion in the treatment of severe poisoning, its further declining use in the future, at least in its present design, and some promising new treatments are emphasized.

Human & Experimental Toxicology, Vol. 5, No. 1, 11-14 (1986)
DOI: 10.1177/096032718600500103


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