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An Association of Mercury with Selenium in Inorganic Mercury Intoxication

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

T. Higuchi

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

R. Kidokoro

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

R. Fukumura

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

A. Yagi

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

S. Ohguchi

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

A. Sasa

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

H. Hayashi

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

N. Sakamoto

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

T. Hanaichi

Department of Medicine, Chubu Rohsai Hospital, Minato-ku, Nagoya 455, Department of Medicine and Electronmicroscope Center, Nagoya University School of Medicine, Showa-ku, Nagoya 466, Japan

1 Energy dispersive X-ray analysis was performed on the renal tubular cells of two patients with inorganic mercury intoxication.

2 Some lysosomes of these cells consisted of unusual matrices of aggregated electron-dense grains which were positive for mercury, selenium and sulphur.

3 Though maps of the specific X-rays of both mercury and selenium coincided exactly with these lysosomes, the molecular ratio of selenium to mercury ranged between zero and 2.9.

4 It is unlikely that the trace element of selenium and exogenous inorganic mercury are deposited in the lysosomes independent of each other, but rather their coexistence in the characteristic lysosomes strongly suggests a compound formed by binding mercury to the SeH residues of selenoprotein.

Human & Experimental Toxicology, Vol. 4, No. 6, 637-642 (1985)
DOI: 10.1177/096032718500400612


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