This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Osborne, R.J. Articles by Hamer, J. Search for Related Content PubMed Articles by Osborne, R.J. Articles by Hamer, J. Social Bookmarking                         What's this?

Cardiac Arrhythmias during Cytotoxic Chemotherapy: Role of Domperidone

Imperial Cancer Research Fund, Department of Medical Oncology, St Bartholomew's and Hackney Hospitals

M.L. Slevin

Imperial Cancer Research Fund, Department of Medical Oncology, St Bartholomew's and Hackney Hospitals

R.W. Hunter

Department of Gynaecology and Obstetrics, St Bartholomew's Hospital, London, UK

J. Hamer

Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK

1 Four patients receiving platinum-containing chemotherapy were treated with domperidone (20 mg) by slow intravenous injection followed by a continuous infusion for 24 h at a dose of 10 mg 24 h^-1 kg^-1. Cardiac monitoring and plasma potassium and domperidone concentration measurements were performed. Severe cardiac arrhythmias occurred in two patients.

2 A control group of 14 patients treated with similar chemotherapy, without domperidone, also underwent cardiac and plasma potassium monitoring. No significant arrhythmias were seen.

3 The electrophysiologic effects of domperidone are discussed.

4 It is concluded that treatment with intravenous domperidone is associated with the occurrence of cardiac arrhythmias.

Human & Experimental Toxicology, Vol. 4, No. 6, 617-623 (1985)
DOI: 10.1177/096032718500400608


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?