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HPLC Method for Determination of Ergot Alkaloids and Some Derivatives in Human Plasma

M. or

LEK, Pharmaceutical and Chemical Works, Research and Development Department, Ljubljana

J. Culig

Section of Clinical Pharmacology, Department of Medicine Rebro, Clinical Hospital Centre, Zagreb, Yugoslavia

Z. Kopitar

LEK, Pharmaceutical and Chemical Works, Research and Development Department, Ljubljana

D. Milivojevic

LEK, Pharmaceutical and Chemical Works, Research and Development Department, Ljubljana

A. Marui

LEK, Pharmaceutical and Chemical Works, Research and Development Department, Ljubljana

M. Bano

LEK, Pharmaceutical and Chemical Works, Research and Development Department, Ljubljana

1 Ergot alkaloids and their dihydrogenated methanesulphonate (ms) salts were determined and measured in human plasma.

2 High-performance liquid chromatography (HPLC) with fluorometric detection was used for separation of ergot alkaloids in plasma.

3 Several ergot alkaloids and their derivatives, including lysergide (LSD), can be identified in cases of poisoning.

Human & Experimental Toxicology, Vol. 4, No. 6, 601-607 (1985)
DOI: 10.1177/096032718500400606


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