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Use of DTPA for Increasing the Rate of Elimination of Plutonium-238 and Americium-241 from Rodents after their Inhalation as the Nitrates

National Radiological Protection Board, Chilton, Didcot, Oxfordshire OX11 ORQ, UK

G.N. Stradling

National Radiological Protection Board, Chilton, Didcot, Oxfordshire OX11 ORQ, UK

S.A. Gray

National Radiological Protection Board, Chilton, Didcot, Oxfordshire OX11 ORQ, UK

J. Moody

National Radiological Protection Board, Chilton, Didcot, Oxfordshire OX11 ORQ, UK

A. Hodgson

National Radiological Protection Board, Chilton, Didcot, Oxfordshire OX11 ORQ, UK

This study has shown that:

1 both inhaled (2 µmol/kg) and injected (30 µmol/kg) diethylenetriaminepentaacetic acid (DTPA) can reduce the lung deposit of ²³⁸Pu and 241 Am inhaled as nitrate to about 1% of that in untreated controls;

2 injection of DTPA is more effective than aerosolized DTPA for reducing deposits of ²³⁸ Pu and ²⁴¹Am in the liver and skelton;

3 combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.

Human & Experimental Toxicology, Vol. 4, No. 6, 573-582 (1985)
DOI: 10.1177/096032718500400603


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