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Screening the in vitro Sperm-immobilizing Effect of some Anticancer Drugs

Department of Medicine, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

B.N. Chiang

Department of Medicine, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

J. Ku

Department of Medicine, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

P. Wu

Department of Medicine, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

1 The in vitro sperm-immobilizing effect of seven anticancer agents, namely cyclophosphamide, 5-fluorouracil, cytarabine, mitomycin-C, 6-mercaptopurine, doxorubicin and vinblastine were screened with a transmembrane migration method.

2 Only doxorubicin and vinblastine inhibited human sperm motility.

3 Because colchicine, a microtubular inhibitor, had no sperm-immobilizing effect, we suggest that the sperm membrane is the site of action of these two anticancer drugs to inhibit human sperm motility.

Human & Experimental Toxicology, Vol. 4, No. 4, 461-464 (1985)
DOI: 10.1177/096032718500400412


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