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Human & Experimental Toxicology
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Antipyrine Metabolism in African Villagers

K. Sommers

Department of Pharmacology and Glaxo Institute for Clinical Pharmacology

D.A. van Staden

Department of Family Medicine and Hans Snyckers Institute

J. Moncrieff

Department of Pharmacology and Glaxo Institute for Clinical Pharmacology

H.S. Schoeman

Department of Statistics, University of Pretoria, Pretoria, Republic of South Africa

1 Antipyrine clearance has been measured from serial serum samples in 49 healthy black Africans from a village in Southern Africa.

2 The subjects follow a lifestyle which minimally exposes them to environmental inducing or inhibiting agents. Food is mainly maize cereal, with a protein content of only about 8.8%, together with greens.

3 Antipyrine clearance, half-life and apparent volume of distribution (mean ± SD) were, respectively, 0.538 ± 0.163 ml min-1 kg-1, 14.81 ± 6.5 h and 0.626 ± 0.075 litre/kg. These results do not differ significantly from the mean values found in a group of lactovegetarian Indo-Pakistani immigrants to Britain.

4 This would suggest that the major environmental determinant influencing hepatic mixed-function oxidase activity is the presence or absence of meat in the diet. However, the relative contributions of environment and heredity will be difficult to determine.

Human & Experimental Toxicology, Vol. 4, No. 4, 379-384 (1985)
DOI: 10.1177/096032718500400403
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