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Effects of Retinoids on Human Lymphocyte Functions in vitroDepartment of Family and Community Medicine, Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA
Department of Family and Community Medicine, Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA
Department of Family and Community Medicine, Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA 1 E-Rosette formation in vitro, lymphocyte mitogenesis and natural killer (NK) activity of human blood lymphocytes were strongly inhibited by high concentration (10 -4 M) of retinol or retinal. Other retinoids at 10-4 M (retinoic acid and 13-cis-retinoic acid) and lower concentrations (10-7 or 10-9 M) of retinol, retinal and carotenes also inhibited E-rosette formation. 2 Lymphocyte transformation responses induced by concanavalin A (Con A) or pokeweed mitogen (PWM) were also inhibited while NK activity was not affected. 3 There was a remarkable depression of the total number of viable lymphocytes after incubation with retinol or retinal 10-4 M. However, other retinoids, 10-7 and 10-9 M of retinol and retinal and carotenes did not show marked decrease of lymphocyte number or viability even after prolonged incubation (48 h). 4 The mechanism of inhibition by retinol or retinal (10-4 M) is due in part to the decrease of viable lymphocytes. It is unclear how other retinoids, carotenes and lower concentrations (10-7 or 10-9 M) of retinol or retinal inhibit E-rosette formation or lymphocyte transformation.
Human & Experimental Toxicology, Vol. 4, No. 4,
365-378 (1985) |
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