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Human & Experimental Toxicology
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Antipyrine Clearance and {alpha}1-Acid Glycoprotein Levels after Isotretinoin

J.R. Marsden

Department of Dermatology and 'Clinical Pharmacology, University of Newcastle upon Tyne

S. Shuster

Department of Dermatology and 'Clinical Pharmacology, University of Newcastle upon Tyne

J.D. Dennis

Department of Dermatology and 'Clinical Pharmacology, University of Newcastle upon Tyne

Eight male subjects aged 18-24 years were treated with 0.5 mg of isotretinoin day-1 kg -1. After 4 weeks levels of cholesterol (P < 0.05) and triglyceride (P < 0.05) were increased and levels of high-density lipoprotein (HDL)-cholesterol were decreased (P < 0.05). Concentrations of aspartate aminotransferase (P < 0.01) and {gamma}-glutamyltranspeptidase (P < 0.01) were higher after treatment; increased alkaline phosphatase and a reduction in bilirubin levels did not reach statistical significance. Values for thyroxine were reduced after isotretinoin and free thyroxine index was lower (P < 0.01). Measurements of salivary clearance of antipyrine and levels of {alpha} 1-acid glycoprotein were lower after treatment but these differences did not reach statistical significance. The findings suggest that there is a small decrease in hepatic microsomal-enzyme activity after isotretinoin and that the unwanted effects on lipids, liver and thyroid function are unlikely to be due to hepatic microsomal-enzyme induction.

Human & Experimental Toxicology, Vol. 4, No. 3, 335-338 (1985)
DOI: 10.1177/096032718500400317
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