This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Plavsic, F. Articles by Culig, J. Search for Related Content PubMed Articles by Plavsic, F. Articles by Culig, J. Social Bookmarking                         What's this?

Determination of Serum Diclofenac by High-performance Liquid Chromatography by Electromechanical Detection

Section of Clinical Pharmacology, Department of Medicine, Clinical Hospital Centre Zagreb, Medical Faculty University of Zagreb, Yugoslavia

J. ulig

Section of Clinical Pharmacology, Department of Medicine, Clinical Hospital Centre Zagreb, Medical Faculty University of Zagreb, Yugoslavia

Diclofenac was isolated from plasma by double extraction with organic solvent. Chromatography was performed on Lichrosorb NH2 column with acetonitrile and perchloric acid (0.0025 mol/l; 35:65, v/v) as the mobile phase (flow rate 0.9 ml/min). The electrochemical detector was operated at +900 mV and sensitivity of 5-10 nA. The sensitivity of the method was 10 µg/1 and the coefficients of variation below 10% in the entire range of the concentration in a dose interval.

Human & Experimental Toxicology, Vol. 4, No. 3, 317-322 (1985)
DOI: 10.1177/096032718500400313


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?