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Human & Experimental Toxicology
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Plasma Protein Changes in Rats Treated with Hypolipidaemic Drugs and with Phthalate Esters

R.H. Hinton

Robens Institute of Industrial and Environmental Health and Safety, University of Surrey,. Guildford, Surrey GU2 5XH, UK

S.C. Price

Robens Institute of Industrial and Environmental Health and Safety, University of Surrey,. Guildford, Surrey GU2 5XH, UK

F.E. Mitchell

Robens Institute of Industrial and Environmental Health and Safety, University of Surrey,. Guildford, Surrey GU2 5XH, UK

A. Mann

Robens Institute of Industrial and Environmental Health and Safety, University of Surrey,. Guildford, Surrey GU2 5XH, UK

D.E. Hall

Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH, UK

J.W. Bridges

Robens Institute of Industrial and Environmental Health and Safety, University of Surrey,. Guildford, Surrey GU2 5XH, UK

1 Treatment of rats with hypolipidaemic drugs or with the plasticizer di-2-ethyl hexyl phthalate caused significant alterations in the concentration of certain plasma proteins.

2 Certain proteins showed dose-dependent increases, in other cases the plasma concentrations fell in treated animals.

3 The changes were quite distinct from the changes in plasma proteins which occur during the acute-phase response to inflammatory agents.

4 Some changes appeared specific to agents which produce peroxisome proliferation in liver, other alterations appeared associated with mild, but sustained, liver injury.

Human & Experimental Toxicology, Vol. 4, No. 3, 261-271 (1985)
DOI: 10.1177/096032718500400306
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