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A Case of Fatal Endrin PoisoningNational Institute of Public Health and Environmental Hygiene, PO Box 1, 3720 BA Bilthoven, Department of Reanimation and Clinical Toxicology, University Hospital Utrecht, Catharijnesingel 101, 3500 CG Utrecht
National Institute of Public Health and Environmental Hygiene, PO Box 1, 3720 BA Bilthoven, Department of Reanimation and Clinical Toxicology, University Hospital Utrecht, Catharijnesingel 101, 3500 CG Utrecht
National Institute of Public Health and Environmental Hygiene, PO Box 1, 3720 BA Bilthoven
State Laboratory Forensic Pathology, Volmerlaan 17, 2288 GD Rijswijk, The Netherlands 1 Ingestion of 12 g of endrin by a 49-year-old man caused convulsions persisting for 4 days, hypersalivation, hyperthermia, renal insufficiency, thrombocytopenia and recurrent hypotension. Death followed after 11 days, due to pulmonary complications (infection and haemorrhage) and hypoxaemia causing bradycardia and cardiac arrest. 2 Endrin and dieldrin concentrations in blood 4 hours, 6 and 11 days after ingestion were respectively 450, 86 and 71 µg/l for endrin and 60, 19 and 19 µg/l for dieldrin. Dieldrin was also present, possibly because the endrin preparation contained traces of dieldrin. 3 Endrin concentrations 11 days after ingestion were 0.071 mg/l in blood, in adipose tissue 89.5 mg/kg, in the heart 0.87 mg/kg, in the brain 0.89 mg/kg, in the kidneys 0.55 mg/kg and in the liver 1.32 mg/kg.
Human & Experimental Toxicology, Vol. 4, No. 3,
241-247 (1985) |
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