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Arsenic Speciation in Urine from Humans Intoxicated by Inorganic Arsenic Compounds

Department of Forensic Medicine and Science, University of Glasgow, Glasgow G12 8QQ, Scotland, UK

J.G. Farmer

Department of Forensic Medicine and Science, University of Glasgow, Glasgow G12 8QQ, Scotland, UK

Trends in the urinary concentrations of the four arsenic species, pentavalent [As (V)] and trivalent [As (III)] inorganic arsenic, monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA), were followed for several days subsequent to the acute intoxication of two human subjects by arsenic trioxide [As (III)₂O₃] and sodium orthoarsenate [Na₂HAs(V)O₄.7H₂O], respectively, in unsuccessful suicide attempts. Total arsenic concentrations ranged from 1.6 to 18.7 mg/l. The increasing predominance of the less toxic methylated species, especially DMAA, after 3 or 4 days supports the concept of methylation as a natural detoxification mechanism as part of an overall reduction/methylation sequence involved in the biotransformation of inorganic arsenic by the human body. However, the additional possibility of oxidation of As(III) to As(V) in vivo under extreme immediate postingestion conditions is suggested by initial high urinary As(V) after arsenic trioxide intoxication. Relative proportions of As(V), As(III), MMAA and DMAA in both cases probably reflect species-dependent differences in rates of direct elimination and reactivity with tissues as well as the efficiency of methylation.

Human & Experimental Toxicology, Vol. 4, No. 2, 203-214 (1985)
DOI: 10.1177/096032718500400211


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