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Human & Experimental Toxicology
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Effect of Chronic Anticonvulsant Monotherapy on Lymphocyte Subpopulations in Adult Epileptic Patients

M. Marcoli

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

G. Gatti

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

G. Ippoliti

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

M. Lombardi

Neurologic Clinic, University of Pavia, P.zza Botta 10, I-27100 Pavia, Italy

A. Crema

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

M.T. Zocchi

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

F. De Ponti

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

S. Lecchini

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

G.M. Frigo

Department of Internal Medicine and Therapeutics, Sections of Pharmacology and Medical Clinic Clinical Pharmacology Unit

Sixty-five patients undergoing long-term monotherapy for at least 3 months with phenytoin, carbamazepine or phenobarbital were screened for lymphocyte and immunoglobulin abnormalities. In 57% of patients the duration of therapy was longer than 12 months. The control subjects were matched for sex and age and none of them was taking drugs. The average serum immunoglobulin (IgG, IgA, IgM) values did not differ in control and patient groups. A significant decrease of OKT4+ cells was seen with all drugs, while other lymphocyte subpopulations were differently affected depending on the drug used. It is concluded that long-term single-drug treatment with phenytoin, carbamazepine and phenobarbital exhibits immunosuppressant effects through a complex action which involves more than one lymphocyte subpopulation. Moreover, the possible interference of the disease state with the immune functions of epileptic patients is discussed.

Human & Experimental Toxicology, Vol. 4, No. 2, 147-157 (1985)
DOI: 10.1177/096032718500400205
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