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Human & Experimental Toxicology
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Massive Theophylline Intoxication: Effects of Charcoal Haemoperfusion on Plasma and Erythrocyte Theophylline Concentrations

R.G. van Kesteren

Department of Reanimation and Clinical Toxicology, University Hospital Utrecht

A. van Dijk

Department of Hospital Pharmacy, Laboratory for Therapeutic Drug Monitoring and Analytical Toxicology, University Hospital Utrecht, Catharijnesingel 101, 3511 GV Utrecht, The Netherlands

S.W. Klein

Department of Hospital Pharmacy, Laboratory for Therapeutic Drug Monitoring and Analytical Toxicology, University Hospital Utrecht, Catharijnesingel 101, 3511 GV Utrecht, The Netherlands

A.N.P. van Heijst

Department of Reanimation and Clinical Toxicology, University Hospital Utrecht

1 The results of a charcoal haemoperfusion on plasma and erythrocyte theophylline concentrations are described in a patient, intentionally intoxicated with a sustained-release theophylline formulation.

2 It is demonstrated that the charcoal-filled Gambro Adsorba 300-C column is effective in removing theophylline.

3 This effectiveness is based on pharmacokinetic parameters, which are presented.

4 The necessity of measuring plasma and erythrocyte theophylline concentrations is outlined. Calculations based on plasma theophylline concentrations only can lead to an underestimation of the effectiveness.

Human & Experimental Toxicology, Vol. 4, No. 2, 127-134 (1985)
DOI: 10.1177/096032718500400203
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