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Human & Experimental Toxicology
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Delayed Gastric Emptying with Dothiepin

K.W. Woodhouse

Department of Medicine, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK

D.N. Bateman

Department of Medicine, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK

Dothiepin induced symptoms of delayed gastric emptying in an elderly lady. Rechallenge studies were undertaken and demonstrated a delay in gastric emptying of liquid after re-administration of dothiepin at a time when plasma concentrations were 93 µg/l. Elderly patients may be more susceptible to the anticholinergic effects of tricyclic antidepressants on the gut.

Human & Experimental Toxicology, Vol. 4, No. 1, 67-70 (1985)
DOI: 10.1177/096032718500400108
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