SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Iversen, S.A.
Right arrow Articles by Gertner, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Iversen, S.A.
Right arrow Articles by Gertner, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Unsuspected Caffeine Toxicity Complicating Theophylline Therapy

S.A. Iversen

Department of Chemical Pathology, University College Hospital

P.G. Murphy

Department of Chemical Pathology, University College Hospital

T.E.B. Leakey

Academic Department of Child Health, Queen Elizabeth Hospital for Children, Hackney Road, Bethnal Green, London

A. Rydlewski

Academic Department of Child Health, Queen Elizabeth Hospital for Children, Hackney Road, Bethnal Green, London

R.D. Levy

Department of Medicine and Clinical Pharmacology, University College Hospital, Gower Street, London, UK

D. Gertner

Department of Medicine and Clinical Pharmacology, University College Hospital, Gower Street, London, UK

1 A 58-year-old man with a history of alcoholic liver disease and chronic airflow obstruction presented with heart failure and acute bronchitis.

2 Plasma methylxanthines were estimated as a guide to further theophylline therapy and serious caffeine accumulation was noted in the presence of a subtherapeutic concentration of theophylline.

3 After 3 weeks on a caffeine-free diet theophylline and caffeine challenge tests were performed which demonstrated the ease with which caffeine could accumulate.

4 The importance of caffeine accumulation during theophylline therapy is discussed.

Human & Experimental Toxicology, Vol. 3, No. 6, 509-512 (1984)
DOI: 10.1177/096032718400300606
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement