SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Marrs, T.C.
Right arrow Articles by Brown, R.F.R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Marrs, T.C.
Right arrow Articles by Brown, R.F.R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Inhalation Toxicity of a Smoke Containing Solvent Yellow 33, Disperse Red 9 and Solvent Green 3 in Laboratory Animals

T.C. Marrs

Procurement Executive, Ministry of Defence Chemical Defence Establishment, Porton Down, Salisbury, Wilts. SP4 OJQ, UK

H.F. Colgrave

Procurement Executive, Ministry of Defence Chemical Defence Establishment, Porton Down, Salisbury, Wilts. SP4 OJQ, UK

M. Gazzard

Procurement Executive, Ministry of Defence Chemical Defence Establishment, Porton Down, Salisbury, Wilts. SP4 OJQ, UK

R.F.R. Brown

Procurement Executive, Ministry of Defence Chemical Defence Establishment, Porton Down, Salisbury, Wilts. SP4 OJQ, UK

The repeated-dose inhalation toxicity of a smoke containing a mixture of three dyes was tested in female mice, rats and guinea pigs. The green component dye (Solvent Green 3) was retained in the lungs. Particularly in the rats marked collections of alveolar macrophages were found. In the same species several other adverse findings were noted: these included adenocarcinomas of the breast in the high-dose group and a dose-related incidence of biliary hyperplasia. Fatty change was noted in the livers of the test-group mice. A large proportion of the high-dose guinea pigs died during the exposure period, for which reason exposure was stopped early in that group, otherwise the guinea pigs were little affected. However, all test groups of all species showed reductions in growth during the exposure period.

Human & Experimental Toxicology, Vol. 3, No. 4, 289-308 (1984)
DOI: 10.1177/096032718400300405
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement