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Human & Experimental Toxicology
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Glutathione and Caffeine Antagonize the Sperm-Immobilizing Effect of a Vaginal Contraceptive

C.Y. Hong

Departments of Medicine and Biochemistry, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

B.N. Chiang

Departments of Medicine and Biochemistry, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

J. Ku

Departments of Medicine and Biochemistry, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

Y.H. Wei

Departments of Medicine and Biochemistry, Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

1 The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method.

2 Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm.

3 Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione.

4 Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.

Human & Experimental Toxicology, Vol. 3, No. 4, 271-277 (1984)
DOI: 10.1177/096032718400300403
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