This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Leslie, P.J.A. Articles by Proudfoot, A.T. Search for Related Content PubMed Articles by Leslie, P.J.A. Articles by Proudfoot, A.T. Social Bookmarking                         What's this?

Lactic Acidosis, Hyperglycaemia and Convulsions following Nalidixic Acid Overdosage

Regional Poisoning Treatment Centre, The Royal Infirmary, Edinburgh EH3 9YW

R.J. Cregeen

Regional Poisoning Treatment Centre, The Royal Infirmary, Edinburgh EH3 9YW

A.T. Proudfoot

Regional Poisoning Treatment Centre, The Royal Infirmary, Edinburgh EH3 9YW

1 A woman survived ingestion of 32 g nalidixic acid despite developing lactic acidosis, hyperglycaemia, convulsions and abnormal behaviour.

2 The maximum recorded plasma concentration of nalidixic acid was 185 mg/l and the elimination half-life was 3.2 h.

3 Carboxy-nalidixic acid was demonstrated in the plasma.

4 Previously reported cases of nalidixic acid overdosage are reviewed.

Human & Experimental Toxicology, Vol. 3, No. 3, 239-243 (1984)
DOI: 10.1177/096032718400300308


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?