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Human & Experimental Toxicology
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Pharmacokinetics of Dextropropoxyphene and Nordextropropoxyphene in Elderly Hospital Patients after Single and Multiple Doses of Distalgesic. Preliminary Analysis of Results

P. Crome

George Stamp Unit, Orpington Hospital, Orpington, Kent BR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK

R. Gain

George Stamp Unit, Orpington Hospital, Orpington, Kent BR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK

R. Ghurye

George Stamp Unit, Orpington Hospital, Orpington, Kent BR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK

R.J. Flanagan

George Stamp Unit, Orpington Hospital, Orpington, Kent BR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK

1 The plasma elimination half-life of dextropropoxyphene and its metabolite nordextropropoxyphene was investigated in seven elderly hospital patients after the administration of both single and multiple doses of Distalgesic.

2 The mean elimination half-life of dextropropoxyphene after multiple dosing was 35.7 h (range 24.0-50.6 h) and the mean half-life of nordextropropoxyphene was 53.3 h (range 25.1-76.3 h).

3 The half-lives of both dextropropoxyphene and nordextropropoxyphene are much longer than those reported by other investigators in younger subjects.

Human & Experimental Toxicology, Vol. 3, No. 1 suppl, 41s-48S (1984)
DOI: 10.1177/096032718400300105
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