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Transplacental Carcinogenesis with Radioactive Phosphorus: The Effects of Promoting Agents

Department of Morbid Anatomy, The London Hospital, London El 1BB

C. Nickols

Department of Morbid Anatomy, The London Hospital, London El 1BB

K.V. Swettenham

Department of Morbid Anatomy, The London Hospital, London El 1BB

1 In a previous experiment, using ³²P as a potential transplacental carcinogen in rats, we found that the isotope caused life-span shortening, reduced growth and caused ante-dating of the time of the tumour occurrence.

2 Liver cell changes (nuclear atypia, variation in cell size) were noted and suggested liver cell damage, possible 'initiation'.

3 A phorbol ester (TPA) and a high fat/high protein diet were used as promoting agents on further transplacentally irradiated rats.

4 The results were identical to the previous experiment; no evidence of promotion was found.

Human & Experimental Toxicology, Vol. 3, No. 1, 45-50 (1984)
DOI: 10.1177/0960327184003001061


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