SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Tedeschi, G.
Right arrow Articles by Richens, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Tedeschi, G.
Right arrow Articles by Richens, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effect of Meptazinol and Ethanol on Human Psychomotor Performance and Mood Ratings

G. Tedeschi

Clinica Neurologica (R), University of Naples, Piazza Miraglia 2, Naples, Italy

A.T. Smith

Department of Medical Electronics, St Bartholomew's Hospital, London EC1A 7BE

A. Richens

Department of Pharmacology & Therapeutics, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN

The effect of meptazinol and/or ethanol on human psychomotor performance and mood ratings has been investigated in 8 healthy volunteers in a double blind randomised study. Meptazinol (200 mg 3 hourly for 4 doses) or placebo were administered orally and ethanol (0.8 g/kg) or placebo were given 30 min after the last tablet. Peak saccadic velocity (PSV), saccade duration at 30° of amplitude (SD), smooth pursuit velocity (SPV), critical flicker fusion threshold (CFF), choice reaction time (CRT) and visual analogue scales were assessed. PSV (p < 0.01), SD (p < 0.001) and SPV (p < 0.01) were significantly impaired after ethanol, while CFF, CFT and visual analogue scales showed no significant effect. None of the tests was affected by the meptazinol treatment alone. No changes were observed in the ethanol-induced impairment of PSV, SD and SPV when meptazinol was given in combination with ethanol.

Human & Experimental Toxicology, Vol. 3, No. 1, 37-43 (1984)
DOI: 10.1177/0960327184003001051
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement