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Human & Experimental Toxicology
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Oxidative stress induced by morphine in brain of rats fed with a protein deficient diet

David Calderón-Guzmán

Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP), México

Norma Osnaya-Brizuela

Laboratorio de Patología Experimental, INP, México

Raquel García-Alvarez

Laboratorio de Farmacología, INP, México

Ernestina Hernández-García

Laboratorio de Farmacología, INP, México

Hugo Juárez-Olguín

Laboratorio de Farmacología, INP, México, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, juarezol{at}yahoo.com

The objective of the study is to determine the damage by oxidative stress induced by morphine in brain of rats fed with a protein-deficient diet. Twenty-eight malnourished male Wistar rats, 30 days old, were used in the study. The animals were divided into four groups of 7 rats per group. Group I received NaCl and the groups II; III and IV intraperitoneally received 3, 6 and 12 mg/kg of morphine sulphate, respectively, in a single dose. Animals were sacrificed and the levels of glutathione (GSH), dopamine, tryptophan and 5-hydroxyindole-3-acetic acid (5-HIAA) as well as, Na+/K+ ATPase and total ATPase activity in the brain were measured. Tryptophan levels and Na+/K + ATPase activity showed non-significant changes in the experimental group. Levels of 5-HIAA decreased significantly (p = .03) in animals that received 12 mg/kg of morphine and in animals that received 3 mg/kg, levels of GSH and dopamine were found to have a significant decrease (p < .05), but a significant increase in the group that received 12 mg/kg of morphine (p < .05). Total ATPase activity increased significantly in the groups that received 3 mg/kg (p = .015) and 6 mg/kg (p = .0001) of morphine. The results show that malnutrition induces changes in cellular regulation and biochemical responses to oxidative stress caused by morphine sulphate.

Key Words: Biogenic amines • brain • glutathione • malnutrition • morphine • oxidative stress

This version was published on September 1, 2009

Human & Experimental Toxicology, Vol. 28, No. 9, 577-582 (2009)
DOI: 10.1177/0960327109102798
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