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Human & Experimental Toxicology
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Liquid flame spray for generating metal and metal oxide nanoparticle test aerosol

JM Mäkelä

Aerosol Physics Laboratory, Tampere University of Technology (TUT), Tampere, Finland, jyrki.makela{at}tut.fi

M. Aromaa

Aerosol Physics Laboratory, Tampere University of Technology (TUT), Tampere, Finland

A. Rostedt

Aerosol Physics Laboratory, Tampere University of Technology (TUT), Tampere, Finland

TJ Krinke

TSI GmbH, Particle Instruments, Aachen, Germany

K. Janka

Dekati Ltd, Tampere, Finland

M. Marjamäki

Aerosol Physics Laboratory, Tampere University of Technology (TUT), Tampere, Finland

J. Keskinen

Aerosol Physics Laboratory, Tampere University of Technology (TUT), Tampere, Finland

A flame-based method for generating nanoparticles with production rate in the order of g/min is presented to be used in a variety of applied studies concerning nanoparticle measurements and toxicological tests. In this study, ferric oxide, titanium dioxide, and silver nanoparticles were produced by this technique, as an example of the variety of producible compounds, and number and surface area were measured by state-of-art aerosol instruments. In the primary experiments of this study, the generator was used in a conventional way, in a fume cupboard, and the aerosol was measured from the exhaust duct of the cupboard. It has been shown that this steady, turbulent flame generator is also suitable for producing high-concentration aerosols in a wider concept. The generated aerosol was measured by variety of aerosol instrumentation to show the applicability of the generator. When using the generator intentionally as a source of aerosol in the flame processing room, mean nanoparticle sizes of 5—60 nm and active surface area concentration ranges of 1—10,000 µm2/cm 3 were covered for the room aerosol.

Key Words: aerosol surface area concentration • engineered nanoparticles • liquid flame spray

Human & Experimental Toxicology, Vol. 28, No. 6-7, 421-431 (2009)
DOI: 10.1177/0960327109105154


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