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Development of a highly controlled gas-phase nanoparticle generator for inhalation exposure studies

Fine Particle and Aerosol Technology Laboratory, Department of Environmental Science, University of Kuopio, Kuopio, Finland, mirella.miettinen{at}uku.fi

J. Riikonen

Laboratory of Industrial Physics, Department of Physics, University of Turku, Turku, Finland

U. Tapper

Fine Particles, Technical Research Centre of Finland, Espoo, Finland

U. Backman

Fine Particles, Technical Research Centre of Finland, Espoo, Finland

J. Joutsensaari

Department of Physics, University of Kuopio, Kuopio, Finland

A. Auvinen

Fine Particles, Technical Research Centre of Finland, Espoo, Finland

VP Lehto

Department of Physics, University of Kuopio, Kuopio, Finland

J. Jokiniemi

Fine Particle and Aerosol Technology Laboratory, Department of Environmental Science, University of Kuopio, Kuopio, Finland, Fine Particles, Technical Research Centre of Finland, Espoo, Finland

We have developed a gas-phase nanoparticle generator that produces stable and well-defined size distributions for TiO₂. The online analyses of the gas-phase compounds and total number concentration of the generated particles as well as the off-line analysis of the filter samples confirmed the stability of the production. The major advantage of this reactor is that the test substance is directly in the aerosol phase, and thus no preprocessing is needed. This eliminates the physicochemical changes between bulk and administrated material during storing or processing. This system is easy to adjust to different experimental setups and precursors. As a result, well-characterized nanomaterials for inhalation exposure studies can be produced. At mass concentration of 30 mg/Nm³, the count mean diameter was 126 nm (geometric SD 1.6), mass mean diameter was 161 nm (2.0), mass median aerodynamic diameter was 125 nm, and the concentrations of harmful gas-phase by-products remained low. The produced powder consisted of crystals of anatase (77 vol%) and brookite (23 vol%), and its specific surface area was 69 m²/g.

Key Words: gas-phase synthesis • inhalation exposure • nanoparticles • stable production • TiO2

Human & Experimental Toxicology, Vol. 28, No. 6-7, 413-419 (2009)
DOI: 10.1177/0960327109105155


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