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Human & Experimental Toxicology
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A nanobiological approach to nanotoxicology

JF Nyland

Department of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine, Columbia, South Carolina, USA

EK Silbergeld

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, esilberg{at}jhsph.edu

There is an urgent need to develop efficient and rapid strategies in order to characterize the potential health risks associated with nanomaterials, given the speed with which applications and uses are increasing. Use of standard toxicity methods will not be sufficient to meet this need. This article proposes the adoption of two novel guidances: the system’s biological approach to toxicity testing advocated by the US National Research Council and a nanobiological perspective that identifies key events at the nanoscale that are relevant to signal transduction and structural biology.

Key Words: nanomaterial • molecular biology • toxicology

Human & Experimental Toxicology, Vol. 28, No. 6-7, 393-400 (2009)
DOI: 10.1177/0960327109105161


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