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A nanobiological approach to nanotoxicologyDepartment of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine, Columbia, South Carolina, USA
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, esilberg{at}jhsph.edu There is an urgent need to develop efficient and rapid strategies in order to characterize the potential health risks associated with nanomaterials, given the speed with which applications and uses are increasing. Use of standard toxicity methods will not be sufficient to meet this need. This article proposes the adoption of two novel guidances: the systems biological approach to toxicity testing advocated by the US National Research Council and a nanobiological perspective that identifies key events at the nanoscale that are relevant to signal transduction and structural biology.
Key Words: nanomaterial molecular biology toxicology
Human & Experimental Toxicology, Vol. 28, No. 6-7,
393-400 (2009) |
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