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Human & Experimental Toxicology
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research-article

Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability

BS Sachin

Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

P Monica

Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

SC Sharma

Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

NK Satti

Natural Products Chemistry, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

MK Tikoo

Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

AK Tikoo

Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

KA Suri

Natural Products Chemistry, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

BD Gupta

Natural Products Chemistry, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, India

RK Johri

Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), (Formerly Regional Research Laboratory), Jammu-Tawi, IndiaJohri.rk{at}gmail.com

This study deals with the pharmacokinetic interaction of selected anti-TB drugs with a natural product (CC-1a) derived from caraway (Carum carvi, L.) seed. CC-1a, chemically standardized butanolic fraction, enhanced the plasma levels of rifampicin, pyrazinamide, and isoniazid in Wistar rat, resulting in increased bioavailability indices (Cmax and AUC) of the drugs. Moreover, a 40% reduced dose regimen of these drugs, which additionally contained CC-1a, was equivalent in terms of Cmax and AUC to a normal dose regimen. A permeation-enhancing property of CC-1a across small intestinal absorptive surface was found to be a contributing factor in its bioavailability enhancing profile.

Key Words: caraway • Carum carvi bioavailability enhancement • isoniazid • permeation • pyrazinamide • rifampicin

Human & Experimental Toxicology, Vol. 28, No. 4, 175-184 (2009)
DOI: 10.1177/0960327108097431
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