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Association of pesticide exposure, vaccination response, and interleukin-1 gene polymorphismsNofer Institute of Occupational Medicine, Lodz, Poland
Department of Epidemiology, Maastricht University, the Netherlands
University Hospital Luigi. Sacco, Milan, Italy
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland
Department of Epidemiology, Maastricht University, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands henk.van.loveren{at}rivm.nl
We performed a cross-sectional study involving workers from four European countries in which exposure to pesticides and immune parameters were evaluated over a short period of time. The total study population consisted of 238 workers occupationally exposed to pesticides and 198 nonoccupationally exposed workers. The study showed that pesticide exposure at levels encountered by workers under different conditions in Europe did not affect the ability of the immune system to respond to vaccination. We could, however, identify individuals within the group of pesticide exposed workers who were genetically characterized by the 2.2 IL-1
Key Words: immunotoxicity • immuno suppression • genetics • cross-sectional • EPI study
Human & Experimental Toxicology, Vol. 27, No. 9,
709-713 (2008) |
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polymorphism and who showed a lower antibody response, pointing out the importance of the understanding of genetic variability and the interaction between genetic and environmental factors in the identification of high-risk individuals, which may eventually lead to preventive measures.