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Is β-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?

Department of Emergency Medicine, University Hospitals Leuven, Leuven, Belgium Marc.Sabbe{at}uzleuven.be

D Desruelles

Department of Emergency Medicine, University Hospitals Leuven, Leuven, Belgium

W Lissens

Center for Medical Genetics, University Hospital Brussels, Brussels, Belgium

β-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of β-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that β-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans.

Key Words: β-glucuronidase • biomarker • organophosphorus poisoning

Human & Experimental Toxicology, Vol. 27, No. 5, 431-433 (2008)
DOI: 10.1177/0960327108094614


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