This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by González-García, B Articles by Sánchez-Ramírez, B Search for Related Content PubMed PubMed Citation Articles by González-García, B Articles by Sánchez-Ramírez, B Social Bookmarking                         What's this?

Decrease of muscarinic cholinergic receptors expression in placenta from rats exposed to methyl parathion

Graduate program in Biotechnology, Faculty of Chemical Sciences, Autonomous University of Chihuahua, Chihuahua, Chih., Mexico

ME Olave

Faculty of Nursing and Nutrition, Autonomous University of Chihuahua. Chihuahua, Chih., Mexico

E Ramos-Martínez

Pathology Department from Central Hospital, Faculty of Medicine, Autonomous University of Chihuahua, Chihuahua, Chih., Mexico

C González-Horta

Graduate program in Biotechnology, Faculty of Chemical Sciences, Autonomous University of Chihuahua, Chihuahua, Chih., Mexico

M Levario-Carrillo

Medical Research Unit, Clinical Epidemiology of the Mexican Social Security Institute, Chihuahua, Chih., Mexico

B Sánchez-Ramírez

Graduate program in Biotechnology, Faculty of Chemical Sciences, Autonomous University of Chihuahua, Chihuahua, Chih., Mexico bsanche{at}uach.mx

Placental transfer of methyl parathion (MP), an organophosphate pesticide, could involve effects on cholinergic system. To analyze whether placental cholinergic system is altered by prenatal exposure to MP, expression of muscarinic cholinergic receptors (M1 and M2 subtypes; mAChR) was determined in pregnant rats exposed to MP at 0.0, 1.0, 1.5, and 2.0 mg/kg. An immunohistochemical analysis for M1 and M2 mAChR was performed, and the density of the mAChR signal was measured by image analysis. M1 and M2 mAChR were found in the trophoblast present in the labyrinth, with an 18% predominance of M2 over M1 in the non-exposed group. The expression of M1 and M2 mAChR in placentas exposed to MP showed a decrease when compared with the non-exposed group (P < 0.05); a dose–response effect was not detected. These results demonstrate that prenatal exposure to MP causes changes in the placental expression of mAChR M1 and M2, suggesting that related placental cholinergic functions could be affected.

Key Words: methyl parathion • muscarinic cholinergic receptor • organophosphate pesticides • placenta

Human & Experimental Toxicology, Vol. 27, No. 3, 241-246 (2008)
DOI: 10.1177/0960327108091863


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. Acosta-Maldonado, B. Sanchez-Ramirez, S. Reza-Lopez, and M. Levario-Carrillo Effects of exposure to pesticides during pregnancy on placental maturity and weight of newborns: A cross-sectional pilot study in women from the Chihuahua State, Mexico Human and Experimental Toxicology, August 1, 2009; 28(8): 451 - 459. [Abstract] [PDF]