This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Roomi, M. Articles by Niedzwiecki, A Search for Related Content PubMed PubMed Citation Articles by Roomi, M. Articles by Niedzwiecki, A Social Bookmarking                   What's this?

A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice

Dr Rath Research Institute, Santa Clara, California, USA

T Kalinovsky

Dr Rath Research Institute, Santa Clara, California, USA

V Ivanov

Dr Rath Research Institute, Santa Clara, California, USA

M Rath

Dr Rath Research Institute, Santa Clara, California, USA

A Niedzwiecki

Dr Rath Research Institute, Santa Clara, California, USA author{at}drrath.com

Acetaminophen (APAP) overdose is often fatal, leading to fulminant hepatic and renal tubular necrosis in humans and animals. We studied the effect of a nutrient mixture (NM) containing, among other nutrients, lysine, proline, ascorbic acid, N-acetyl cysteine, and green tea extract, which has previously been demonstrated to exhibit a broad spectrum of therapeutic properties on APAP-induced hepatic and renal damage in ICR (Imprinting Control Region) mice. Seven-week-old male ICR mice were divided into four groups (A–D) of five animals each. Groups A and C mice were fed a regular diet for 2 weeks, while groups B and D mice were supplemented with 0.5% NM (w/w) during that period. Groups A and B received saline i.p., while groups C and D received APAP (600 mg/kg) i.p. All animals were killed 24 h after APAP administration, serum was collected to assess the liver and kidney functions, and the livers and kidneys were excised for histology. Mean serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, BUN (Blood Urea Nitrogen), creatinine, and BUN/creatinine ratios were comparable in groups A and B, increased markedly in group C and significantly lower in group D compared with group C. APAP caused significant centrilobular necrosis and glomerular damage in unsupplemented animals, while NM prevented these alterations. The results indicate that NM has potential to protect against APAP-induced liver and kidney damage.

Key Words: acetaminophen • APAP • hepatic • nutrients • renal • toxicity

Human & Experimental Toxicology, Vol. 27, No. 3, 223-230 (2008)
DOI: 10.1177/0960327108090276


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Roomi, T Kalinovsky, N. Roomi, V Ivanov, M Rath, and A Niedzwiecki A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice Human and Experimental Toxicology, July 1, 2008; 27(7): 559 - 566. [Abstract] [PDF]