Human & Experimental Toxicology

 

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Human & Experimental Toxicology, Vol. 27, No. 3, 181-194 (2008)
DOI: 10.1177/0960327107087802

research-article

Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review

R Maciulaitis

Department of Basic and Clinical Pharmacology, Kaunas University of Medicine, Lithuania

V Kontrimaviciute

Clinical Pharmacokinetic Laboratory, Faculty of Pharmacy, University Montpellier I, France; Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, Lithuania

FMM Bressolle

Clinical Pharmacokinetic Laboratory, Faculty of Pharmacy, University Montpellier I, France fbressolle{at}aol.com

V Briedis

Department of Pharmaceutical Technology and Social Pharmacy, Kaunas University of Medicine, Lithuania

Ibogaine is an indole alkaloid derived from the bark of the root of the African shrub Tabernanthe iboga. Psychoactive properties of ibogaine have been known for decades. More recently, based on experimental data from animals and anectodal reports in human, it has been found that this drug has anti-addictive effects. Several patents were published between 1969 and 1995. The pharmacology of ibogaine is quite complex, affecting many different neurotransmitter systems simultaneously. However, the pharmacological targets underlying the physiological and psychological actions of ibogaine are not completely understood. Ibogaine is rapidly metabolized in the body in noribogaine. The purpose of this article was to review data from the literature concerning physicochemical properties, bio-analytical methods, and pharmacology of ibogaine; this article will be focused on the use of this drug as anti-addictive agent.

Key Words: bioanalytical methods • ibogaine • noribogaine • pharmacodynamic studies • pharmacokinetics • safety


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