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Enzymuria determination in children treated with aminoglycosides drugs

Alborz Hospital, Social Security Organization, Karaj, Iran; Department of Pharmacology, School of Medicine, Medical Sciences/ University of Tehran, Iran

S Asgharzadeh-Haghighi

Alborz Hospital, Social Security Organization, Karaj, Iran

M Ghazi-Khansari

Department of Pharmacology, School of Medicine, Medical Sciences/ University of Tehran, Iran ghazikha{at}sina.tums.ac.ir

A Seyed-Ebrahimi

Alborz Hospital, Social Security Organization, Karaj, Iran

A Ghasemi

Alborz Hospital, Social Security Organization, Karaj, Iran

E Jabari

Alborz Hospital, Social Security Organization, Karaj, Iran

Although aminoglycosides antibiotics are used in children and adult commonly, they have serious side effects such as nephrotoxicity and ototoxicity. In clinical practice, for renal function, the levels of serum creatinine and blood urea nitrogen routinely are measured. Since these parameters have limitations such as unreliability, insensitivity, and nonspecificity, the rapid assessment of renal function based on these patients is very important. Increase in N-acetyl-β-D-glucosaminidase (NAG), a hydrolytic lysosomal enzyme, suggests proximal tubular cell damage. In this study, 32 children aged 2 months through 2 years, treated with gentamicin and amikacin for suspected infections at the pediatric ward of Alborz hospital from September 2006 to February 2007, were enrolled. Serum and fresh urine before and after drug infusion were obtained on the 1st, 3rd, and 5th days of antibiotic treatment. Serum urea and creatinine with urinary creatinine, albumin, NAG, lactate dehydrogenase (LDH) and alkaline phosphatase (AP) activity were then determined. A statistically significant increase in urinary NAG, LDH, and AP on 5th day was found compared with before gentamicin administration (P < 0.001, P < 0.01, P < 0.05, respectively). The urinary NAG activity may be a useful indicator of renal injury in children treated with aminoglycosides drugs compared with other routine clinical indicators.

Key Words: aminoglycosides antibiotics • children • serum creatinine • urinary enzymes

Human & Experimental Toxicology, Vol. 27, No. 12, 879-882 (2008)
DOI: 10.1177/0960327108100417


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