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Kaempferol, a mutagenic flavonol from Helichrysum simillimum

Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa

FR van Heerden

School of Chemistry, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa

J van Staden

Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa rcpgd{at}ukzn.ac.za

Helichrysum simillimum is native to South Africa. It is used for the treatment of coughs, colds, fever, infections, headache, and menstrual pain. Extracts of this species showed mutagenic effects in the Salmonella/microsome assay. The aim of this study was to isolate and determine the mutagenic constituents of H. simillimum. Bioassay-guided fractionation of 90% aqueous methanol extracts, using Salmonella typhimurium TA98, led to the isolation of the flavonol kaempferol.

Key Words: Asteraceae • Helichrysum simillimum • kaempferol • mutagenic effect • Salmonella typhimurium TA98

Human & Experimental Toxicology, Vol. 27, No. 11, 845-849 (2008)
DOI: 10.1177/0960327108099532


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