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The ability of Warburgia salutaris extracts to protect against crystalline silica-induced cell injurySchool of Biomedical Technology, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa; National Institute for Occupational Health, Johannesburg, South Africa
Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
School of Biomedical Technology, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa
National Institute for Occupational Health, Johannesburg, South Africa; Department of Haematology and Molecular Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa mary.gulumian{at}nioh.nhls.ac.za
In Southern Africa, the medicinal plant Warburgia salutaris is commonly used for the treatment of inflammatory and other diseases. The methanol extracts of W. salutaris were investigated with regard to a) production of proinflammatory cytokines tumor necrosis factor-
Key Words: antioxidants • DNA damage • inflammation • lipid peroxidation • medicinal plants • silica
Human & Experimental Toxicology, Vol. 27, No. 11,
827-835 (2008) |
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, interleukin-1β, and interferon-
; b) activation of the transcription factor nuclear factor kappa B; and c) induction of deoxyribonucleic acid (DNA) damage and lipid peroxidation in the presence of crystalline silica particles. Due to its antioxidant properties, extracts of W. salutaris showed protective effects against crystalline silica-induced inflammatory cytokine expression, activation of nuclear transcription factor-
B, DNA strand breakage, and lipid peroxidation. Hence, W. salutaris may be a potential therapeutic agent against the fibrogenic and carcinogenic effects of crystalline silica.