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Chloroform deposition in renal cyst fluid of hemodialysis patients with renal cystic disorders

Department of Urology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University, Tochigi, Japan fitour{at}dnh.twmu.ac.jp

H Nakazawa

Department of Urology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan

Y Ohsaka

Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan

T Yagisawa

Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University, Tochigi, Japan

T Kondo

Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan

Y Hashimoto

Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan

Chronic exposure to chloroform (CHCl₃) induces renal neoplasms in rodents and may be carcinogenic in humans, but studies on chronic CHCl₃ deposition in the human body have not been performed. In this study, we examined 27 hemodialysis patients with renal cystic diseases including acquired cystic disease of the kidney (ACDK) accompanied by renal tumors at high frequency. Intracystic and serum CHCl₃ concentrations were determined using a headspace gas chromatography/mass spectrometry analysis. CHCl₃ was not detected in the serum in any cases, but levels ranging from <0.1 to 0.659 mg/L were found in the cyst fluid in most cases, including patients with ACDK and autosomal dominant polycystic kidney disease. Because intracystic CHCl₃ deposition was not confined to ACDK cases, we were unable to evaluate the relationship between CHCl₃ accumulation and carcinogenesis in ACDK. However, our results suggest that compounds such as CHCl₃ accumulate in renal cyst fluid in hemodialysis patients with renal cystic diseases.

Key Words: chloroform • cystic kidney disease • hemodialysis • renal cell carcinoma

Human & Experimental Toxicology, Vol. 27, No. 10, 769-772 (2008)
DOI: 10.1177/0960327108096112


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