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Human & Experimental Toxicology
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Renal and hepatic injury with elevated cardiac enzymes in Amanita phalloides poisoning: a case report

Pinar Unverir

Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey

Burak Cem Soner

Department of Pharmacology, Dokuz Eylul University School of Medicine, Izmir, Turkey

Erhan Dedeoglu

Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey

Ozgur Karcioglu

Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey

Kaya Boztok

Department of Horticulture, Faculty of Agriculture, Ege University, Izmir, Turkey

Yesim Tuncok

Department of Pharmacology, Dokuz Eylul University School of Medicine, Izmir, Turkey, yesim.tuncok{at}deu.edu.tr

Amatoxins are one of the most potent toxins that cause hepatic and renal failure. However, this is the first report demonstrating an elevation of cardiac enzymes in a patient with Amanita phalloides poisoning. A 56-year-old male was admitted to the emergency department (ED) 42 h after an unknown type of mushroom ingestion. Hepatic, renal function tests, amylase and cardiac enzymes (troponin I, creatine kinase (CK), CK-MB isoenzyme and myoglobin) were found elevated in his blood chemistry. The electrocardiogram disclosed sinus tachycardia. Aggressive treatment with fluids, activated charcoal, penicillin G and silibinin were started. The patient was sent to hemodialysis because of anuria. During follow-up, biochemical parameters and clinical findings improved. The patient was discharged from the hospital following the arrangement of hemodialysis schedule because of the chronic renal failure. False elevations of cardiac markers may confuse the clinicians in differantial diagnosis of myocardial infarction in ED. In our patient, amatoxins that have bound the actin filaments within myocardiocytes or renal cells and/or its effects as circulating anti-troponin antibodies might result in elevation of cardiac markers. Elevated cardiac enzyme levels without any acute coronary syndrome are probable in mushroom poisoning cases involving amatoxin ingestion. Human & Experimental Toxicology (2007) 26, 757—761

Key Words: Amanita phalloides • amatoxin • elevation of myocardial enzymes • poisoning • troponin I

Human & Experimental Toxicology, Vol. 26, No. 9, 757-761 (2007)
DOI: 10.1177/0960327107083972
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