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2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity

Department of Occupational Medicine, 1st Medical Faculty, Charles University and General University Hospital, Na Bojiti 1, Prague, Czech Republic, daniela.pelclova{at}lf1.cuni.cz

Martin Prázn

Third Department of Internal Medicine, 1st Medical Faculty, Charles University and General University Hospital, U Nemocnice 1, Prague, Czech Republic

Jan krha

Third Department of Internal Medicine, 1st Medical Faculty, Charles University and General University Hospital, U Nemocnice 1, Prague, Czech Republic

Zdenka Fenclová

Department of Occupational Medicine, 1st Medical Faculty, Charles University and General University Hospital, Na Bojiti 1, Prague, Czech Republic, Centre of Occupational Medicine, National Institute of Public Health, robárova 48, Prague, Czech Republic

Marta Kalousová

Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Karlovo námstí 32, Prague, Czech Republic

Pavel Urban

Department of Occupational Medicine, 1st Medical Faculty, Charles University and General University Hospital, Na Bojiti 1, Prague, Czech Republic, Centre of Occupational Medicine, National Institute of Public Health, robárova 48, Prague, Czech Republic

Tomá Navrátil

Department of Occupational Medicine, 1st Medical Faculty, Charles University and General University Hospital, Na Bojiti 1, Prague, Czech Republic, J. Heyrovsk Institute of Physical Chemistry, AS CR, v.v.i., Dolejkova 3, Prague, Czech Republic

Zdenka enholdová

Department of Occupational Medicine, 1st Medical Faculty, Charles University and General University Hospital, Na Bojiti 1, Prague, Czech Republic

Zdenk merhovsk

Centre of Occupational Medicine, National Institute of Public Health, robárova 48, Prague, Czech Republic

Vascular function was examined in subjects with long-term high level of serum 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) during their follow-up visits. Their earlier mean peak TCDD level at the time of exposure in 1965—1968 was estimated in the range of 3300—74 000 pg/g lipids. Ten former pesticide production workers heavily exposed to TCDD (age 57 ± 2 years, TCDD about 170 pg/g lipids) were examined in 2001. Extended group of 15 TCDD-exposed men (age 59 ± 3 years, TCDD about 130 pg/g lipids) underwent the same examination in 2004. Findings were compared with a control group of 14 healthy men (age 54 ± 2 years). Skin microvascular reactivity (MVR) was measured by laser Doppler perfusion monitoring in the forearm during post-occlusive reactive hyperemia (PORH) and thermal hyperemia (TH). Several parameters of MVR in men exposed to TCDD were significantly impaired, compared with the control group and further progression of the impairment of MVR has been observed between years 2001 and 2004. Serum concentration of E-selectin and inhibitor of tissue plasminogen activator 1 (PAI-1) was significantly higher in exposed subjects (56.0 ± 18.4 ng/mL versus 40.0 ± 12.0 ng/mL, P = 0.022 and 90.9 ± 33.3 ng/mL versus 45.0 ± 18.0, P = 0.002, respectively). In addition, PORH in the forearm was significantly negatively associated with SOD activity (r = —0.77, P = 0.009) as well as the velocity of perfusion increase during TH (r = —0.68, P = 0.03) and TH% (r = —0.78, P = 0.008). Our data document the presence of endothelial dysfunction in TCDD-exposed men. Human & Experimental Toxicology (2007) 26, 705—713

Key Words: 2,3,7,8-TCDD • endothelial dysfunction • oxidative stress • superoxide dismutase

Human & Experimental Toxicology, Vol. 26, No. 9, 705-713 (2007)
DOI: 10.1177/0960327107083971


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