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Human & Experimental Toxicology, Vol. 26, No. 9, 677-685 (2007)
DOI: 10.1177/0960327107083974

Reviews

Short Review: Benzene's toxicity: a consolidated short review of human and animal studies

Haseeb Ahmad Khan

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia, khan_haseeb{at}yahoo.com

A large population of humans is exposed to benzene from various occupational and environmental sources. Benzene is an established human and animal carcinogen. Exposure to benzene has been associated with leukaemia in humans and several types of malignancies in animals. The exact mechanism of benzene-induced toxicity is poorly understood. It is believed that benzene exerts its adverse effects by metabolic activation to toxic metabolites. Certain benzene metabolites are genotoxic and mutagenic. This consolidated short-review is composed of human and animal studies to summarize the adverse effects of benzene with special reference to molecular mechanisms involved in benzene-induced toxicity. Human & Experimental Toxicology (2007) 26, 677—685

Key Words: benzene • chromosomal aberrations • cytotoxicity • genotoxicity • health hazards • mutations • sister chromatid exchange


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